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Jean-Philippe Nougayrède Selected Research

colibactin

12/2022The pks island: a bacterial Swiss army knife? Colibactin: beyond DNA damage and cancer.
12/2021Tackling the Threat of Cancer Due to Pathobionts Producing Colibactin: Is Mesalamine the Magic Bullet?
1/2021Insights into the acquisition of the pks island and production of colibactin in the Escherichia coli population.
1/2021A Toxic Friend: Genotoxic and Mutagenic Activity of the Probiotic Strain Escherichia coli Nissle 1917.
1/2021Uropathogenic E. coli induces DNA damage in the bladder.
12/2020The Polyphosphate Kinase of Escherichia coli Is Required for Full Production of the Genotoxin Colibactin.
1/2020ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in Escherichia coli.
10/2019The Polyamine Spermidine Modulates the Production of the Bacterial Genotoxin Colibactin.
1/2018The Colibactin Genotoxin Generates DNA Interstrand Cross-Links in Infected Cells.
3/2016Escherichia coli ClbS is a colibactin resistance protein.
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Jean-Philippe Nougayrède Research Topics

Disease

8Infections
01/2021 - 08/2003
7Colorectal Neoplasms (Colorectal Cancer)
12/2021 - 03/2016
5Neoplasms (Cancer)
12/2022 - 01/2018
3Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
12/2021 - 11/2012
2Carcinogenesis
10/2019 - 01/2018
2Colonic Neoplasms (Colon Cancer)
01/2018 - 06/2011
1Inflammation (Inflammations)
07/2023
1Long Term Adverse Effects
01/2021
1Ataxia Telangiectasia (Louis Bar Syndrome)
01/2018
1Fanconi Anemia (Fanconi's Anemia)
01/2018
1Lymphopenia (Lymphocytopenia)
07/2014
1Bacteremia
07/2014
1Sepsis (Septicemia)
07/2014
1Leukemia
01/2013
1Chromosomal Instability (Chromosome Stability)
06/2011
1Necrosis
10/2009

Drug/Important Bio-Agent (IBA)

12colibactinIBA
12/2022 - 06/2011
6MutagensIBA
12/2022 - 06/2011
3DNA (Deoxyribonucleic Acid)IBA
01/2021 - 06/2011
2Mesalamine (Mesalazine)FDA LinkGeneric
12/2021 - 12/2020
2Virulence Factors (Pathogenicity Factors)IBA
01/2020 - 01/2018
2Proteins (Proteins, Gene)FDA Link
01/2018 - 10/2009
1CytokinesIBA
07/2023
1Alkylating AgentsIBA
01/2021
1EnzymesIBA
01/2021
1PolyketidesIBA
01/2020
1Analgesics (Analgesic Drugs)IBA
01/2020
1Peptides (Polypeptides)IBA
01/2020
1SpermidineIBA
10/2019
1PolyaminesIBA
10/2019
1Phosphotransferases (Kinase)IBA
01/2018
1Fanconi Anemia Complementation Group D2 ProteinIBA
01/2018
1Antineoplastic Agents (Antineoplastics)IBA
01/2018
1Anti-Bacterial Agents (Antibiotics)IBA
07/2014
11,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA
01/2013
1HeterochromatinIBA
01/2013
1GalactosidasesIBA
01/2013
1L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA
12/2009
1Annexin A5IBA
12/2009
1Caspase 3 (Caspase-3)IBA
12/2009
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
10/2009
1NF-kappa B (NF-kB)IBA
10/2009
1Phosphoric Monoester Hydrolases (Phosphatases)IBA
12/2006
1VaccinesIBA
08/2003

Therapy/Procedure

1Therapeutics
01/2021
1Fluid Therapy (Oral Rehydration Therapy)
07/2014
1Oral Administration
11/2012